Glaucoma is one of the leading causes of blindness in the world. Cannabinoids can effectively lower intraocular pressure and have neuroprotective actions. This helps with the pain associated with Glaucoma, and has been shown to slow its progression.
Effective therapeutic options for patients living with chronic pain are limited. The pain relieving effects of cannabinoids are wide ranging. The discovery of the endocannabinoid system and its role in the control of pain and inflammation, as well as the significant pain relieving and anti-inflammatory characteristics of cannabinoids, provide explanation for the usefulness of cannabinoids in pain treatments.
Many neurological conditions feature a neurodegenerative component that is associated with excitotoxicity, oxidative stress, and neuroinflammation. Cannabinoids have been shown to inhibit these events to halt the progression of neurodegeneration. New cannabinoid therapies continue to emerge as treatments for neurodegenerative conditions of a diverse range, such as Alzheimer's disease, multiple sclerosis, cerebral ischemia, and others.
The endocannabinoid system is implicated in gut homeostasis, modulating gastrointestinal motility, visceral sensation, inflammation, as well as IBD pathogenesis. Cannabinoids are used to treat GI conditions that range from infections and inflammatory conditions to disorders of motility, emesis and abdominal pain. Cannabinoids can also be used to regulate nausea, and metabolism.
The endocannabinoid system modulates neuronal excitability, protects neurons against hyperexcitability, and can regulate seizure activity. Some cannabinoids have long been recognized as having antiepileptic characteristics. While this field of treatment is showing tremendous progress, cannabinoids can exert some paradoxical effects in relation to epilepsy, so due diligence is recommended.
The endocannabinoid system modulates immune response and control of cancer cell proliferation. Cannabinoids offer potential applications as antitumor drugs, based on the ability of some members of this class to limit inflammation, cell proliferation, and cell survival. Emerging evidence and patient testimonials suggest that cannabinoids offer a novel strategy to treat cancer. Cannabis is frequently recommended to treat nausea for patients undergoing chemotherapy.
The endocannabinoid system modulates immune phenomena associated with infection and inflammation. It can be exploited to treat chronic diseases and immune deficiency. Cannabinoids are immunomodulators that modulate immune reactions in the periphery but also in the brain, influence T cell subset balance, and cytokine expression. They also modulate host resistance to bacterial, protozoan, and viral infections.
The role of the endocannabinoid system in emotional homeostasis has been extensively investigated. Endocannabinoid signaling could be dysfunctional in a number of mental disorders. Pharmacological normalization of endocannabinoid system activity represents a novel approach for the treatment of neuropsychiatric disorders, including anxiety disorders, depression, schizophrenia and addiction, as well as stress-related metabolic disorders.