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Another "abstract" Showing That The Us Government Really Does Have A Patent On The Medical Use Of Marijuana

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Another“Abstract” showing that the US Government really does have a patent on themedical use of marijuana.










Patent #: 4876276

Issued on: 10/24/1989

Inventor: Mechoulam, et al.


Methodfor the production of 6,12-dihydro-6-hydroxy-cannabidiol and the use thereoffor the production of trans-delta-9-tetrahydrocannabinol

Patent #: 5227537

Issued on: 07/13/1993

Inventor: Stoss, et al.


NMDA-blockingpharmaceutical compositions

Patent #: 5284867

Issued on: 02/08/1994

Inventor: Kloog, et al.


Neuroprotectivepharmaceutical compositions of 4-phenylpinene derivatives and certain novel4-phenylpinene compounds

Patent #: 5434295

Issued on: 07/18/1995

Inventor: Mechoulam, et al.


Nitroxidesas protectors against oxidative stress

Patent #: 5462946

Issued on: 10/31/1995

Inventor: Mitchell, et al.


Methodof inhibiting oxidants using alkylaryl polyether alcohol polymers

Patent #: 5512270

Issued on: 04/30/1996

Inventor: Ghio, et al.



Patent #: 5521215

Issued on: 05/28/1996

Inventor: Mechoulam, et al.


Certaintetrahydrocannabinol-7-oic acid derivatives

Patent #: 5538993

Issued on: 07/23/1996

Inventor: Mechoulam, et al.


(3S,4S)-delta-6-tetrahydrocannabinol-7-oicacids and derivatives thereof, processors for their preparation andpharmaceutical compositions containing them

Patent #: 5635530

Issued on: 06/03/1997

Inventor: Mechoulam, et al.


More ...


Syntheticcatalytic free radical scavengers useful as antioxidants for prevention andtherapy of disease

Patent #: 5696109

Issued on: 12/09/1997

Inventor: Malfroy-Camine, et al.


Useof cannabinoids as anti-inflammatory agents







Cannabinoids have been found to haveantioxidant properties, unrelated to NMDA receptor antagonism. This new foundproperty makes cannabinoids useful in the treatment and prophylaxis of widevariety of oxidation associated diseases, such as ischemic, age-related,inflammatory and autoimmune diseases. The cannabinoids are found to haveparticular application as neuroprotectants, for example in limitingneurological damage following ischemic insults, such as stroke and trauma, orin the treatment of neurodegenerative diseases, such as Alzheimer's disease,Parkinson's disease and HIV dementia. Nonpsychoactive cannabinoids, such ascannabidoil, are particularly advantageous to use because they avoid toxicitythat is encountered with psychoactive cannabinoids at high doses useful in themethod of the present invention. A particular disclosed class of cannabinoidsuseful as neuroprotective antioxidants is formula (I) wherein the R group isindependently selected from the group consisting of H, CH3, and COCH3. ##STR1##



Other References


•Windholz et al., The Merck Index,Tenth Edition (1983) p. 241, abstract No. 1723.


•Mechoulam et al., "A TotalSynthesis of d1-Ɗ1 -Tetrahydrocannabinol, the Active Constituent ofHashish1," Journal of the American Chemical Society, 87:14:3273-3275(1965)


•Mechoulam et al., "ChemicalBasis of Hashish Activity," Science, 18:611-612 (1970)


•Ottersen et al., "The Crystaland Molecular Structure of Cannabidiol," Acta Chem. Scand. B 31, 9:807-812(1977)


•Cunha et al., "ChronicAdministration of Cannabidiol to Healthy Volunteers and EpilepticPatients1," Pharmacology, 21:175-185 (1980)


•Consroe et al., "Acute andChronic Antiepileptic Drug Effects in Audiogenic Seizure-SusceptibleRats," Experimental Neurology, Academic Press Inc., 70:626-637 (1980)


•Turkanis et al.,"Electrophysiologic Properties of the Cannabinoids," J. Clin.Pharmacol., 21:449S-463S (1981)


•Carlini et al., "Hypnotic andAntielpileptic Effects of Cannabidiol," J. Clin. Pharmacol., 21:417S-427S(1981)


•Karler et al., "The Cannabinoidsas Potential Antiepileptics," J. Clin. Pharmacol., 21:437S-448S (1981)


•Consroe et al., "AntiepilepticPotential of Cannabidiol Analgos," J. Clin. Pharmacol., 21:428S-436S(1981)


•Colasanti et al., "OcularHypotension, Ocular Toxicity,a nd Neurotoxicity in Response to MarihuanaExtract and Cannabidiol," Gen Pharm., Pergamon Press Ltd., 15(6):479-484(1984)


•Colasanti et al., "IntraocularPressure, Ocular Toxicity and Neurotoxicity after Administration of Cannabinolor Cannabigerol," Exp. Eye Res., Academic Press Inc., 39:251-259 (1984)


•Volfe et al., "CannabinoidsBlock Release of Serotonin from Platelets Induced by Plasma frm MigrainePatients," Int. J. Clin. Pharm. Res., Bioscience Ediprint Inc., 4:243-246(1985)


•Agurell et al.,"Pharmacokinetics and Metabolism of Ɗ1 -Tetrahydrocannabinol and OtherCannabinoids with Emphasis on Man*," Pharmacological Reviews, 38(1):21-43(1986)


•Karler et al., "DifferentCannabinoids Exhibit Different Pharmacological and ToxicologicalProperties,"NIDA Res. Monogr., 79:96-107 (1987)


•Samara et al.,"Pharmacokinetics of Cannabidiol in Dogs," Drug Metabolism andDisposition, 16(3):469-472 (1988)


•Choi, "Glutamate Neurotoxicityand Diseases of the Nervous System," Neuron, Cell Press, 1:623-634 (1988)


•Eshhar et al., "Neuroprotectiveand Antioxidant Activities of HU-211, A Novel NMDA Receptor Antagonist,"European Journal of Pharmacology, 283:19-29 (1995)


•Skaper et al., "The ALIAmidePalmitoylethanolamide and Cannabinoids, but not Anandamide, are Protective in aDelayed Postglutamate Paradigm of Excitotoxic Death in Cerebellar GranuleNeurons," Neurobiology, Proc. Natl. Acad. Sci. USA, 93:3984-3989 (1996)



•Alonso et al., "SimpleSynthesis of 5-Substituted Resorcinols: A Revisited Family of InterestingBioactive Molecules," J. Org. Chem., American Chemical Society,62(2):417-421 (1997)


•Combes et al. "A SimpleSynthesis of the Natural 2,5-Dialkylresorcinol Free Radical ScavengerAntioxidant: Resorstation," Synthetic Communications, Marcel Dekker, Inc.,27(21):3769-3778 (1997)


•Shohami et al., "OxidativeStress in Closed-Head Injury: Brain Antioxidant Capacity as an Indicator ofFunctional Outcome," Journal of Cerebral Blood Flow and Metabolism,Lippincott-Raven Publishers, 17(10):1007-1019 (1997)


•Zurier et al., "Dimethylheptyl-THC-11OIC Acid," Arthritis & Rheumatism, 41(1):163-170 (1998)


•Hampson et al., "Dual Effectsof Anandamide on NMDA Receptor-Mediated Responses and Neurotransmission,"Journal of Neurochemistry, Lippincott-Raven Publishers, 70(2):671-676 (1998)


•Hampson et al., "Cannabidioland (-)Ɗ9 -tetrahydrocannabiono are Neuroprotective Antioxidants," MedicalSciences, Proc. Natl. Acad. Sci. USA, 8268-8273 (1998)







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