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Can The Dosing Schedule Impact The Effectiveness Of Treatment?

in vivo

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The average lifespan of a cannabinoid receptor is around 0.5 seconds. Their level of expression (the amount of them) is constantly in flux. Those that have consumed cannabis for extended periods of time are familiar with the fact that a "tolerance" is quickly established. This is in large part due to the level of cannabinoid receptors being lowered by the use of agonists. It's also commonly accepted that short breaks (12-24hrs) from the use of cannabis can lower that tolerance. Well, here's a study that suggests that in a four day period as many as two day breaks from cannabinoids can increase the effectiveness of treatments. This is particularly important in the treatment of cancer and is a technique that should be explored. The breaks might also be likely to increase metabolism, which should help with any complications associated with bowel movements.



Cannabinoids are the bioactive components of the
Cannabis plant that display a diverse range of therapeutic
qualities. We explored the activity of six cannabinoids, used
both alone and in combination in leukaemic cells.
Cannabinoids were cytostatic and caused a simultaneous
arrest at all phases of the cell cycle. Re-culturing pre-treated
cells in drug-free medium resulted in dramatic reductions in
cell viability. Furthermore, combining cannabinoids was not
antagonistic. We suggest that the activities of some
cannabinoids are influenced by treatment schedules;
therefore, it is important to carefully select the most
appropriate strategy in order to maximise their efficacy.


In conclusion, this study adds further support to the idea
that cannabinoids can have a role in the cancer setting, not
only as single agents, but also in combination with each
other. Our findings indicate that cannabinoids act with each
other in a way such that doses for therapy could be reduced
without a significant loss of activity. Additionally, these data
also showed the cytostatic nature of the cannabinoids
hampered cell killing; however, cytotoxicity was restored
when a pulsed-schedule was adopted. It is important that this
observation be expanded so the benefits of recovery phases
are more fully understood, which will ultimately help us to
fashion ways of developing new treatment strategies that
utilise this class of compound.



Edited by in vivo
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I hear ya. I doubt whether most of my patients would be fond of the idea. My explanation may not have been an appropriate one. I was attempting to frame the concept in a way that might be relatable to most board members. In terms of treating cancer, the paper is much more specific. The continued exposure to agonists was shown to "hamper cell killing", while the interrupted schedule did not display this adverse effect.     


If you're taking 1000mg of concentrate a day, this might help with price factors as well.

Edited by in vivo
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