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Survey Of Anti-Hiv And Anti-Hcv Compounds From Natural Sources


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Abstract: This review article describes our recent research on (from 2005 to the end of 2012) isolation
and identification of natural products, their in vivo metabolites and synthesized derivatives as potential
anti-viral agents. Bioactivity assays focused on the inhibition of essential viral enzymes such as HIV
protease, HCV protease, and -glucosidase. Bioactive compounds were structurally classified as lignans,
triterpenes, chlorogenic acid derivatives and farnesyl hydroquinones. The possible mechanisms of
inhibition of a representative triterpene and a farnesyl hydroquinone on HIV-1 protease are discussed. We
structurally modified some known triterpenes (betulinic, oleanolic, ursolic and glycyrrhetic acids,
panaxadiol, panaxatriol) and chlorogenic acid to identify derivatives with improved inhibitory potency or
improved selectivity for viral essential enzymes. Some novel structure-activity relationships (SARs) are
also presented in this paper.

 

 

Keywords: Natural Products, Anti-HIV, HIV Protease Inhibitor, HCV Protease Inhibitor, -Glucosidase
Inhibitor

 

http://canchemtrans.ca/uploads/journals/CCT-2013-0017.pdf

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