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Cbd-Enriched (With Thc) Medical Cannabis For Intractable Pediatric Epilepsy: The Current Israeli Experience.

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cannabis works for reducing seizures in people with epilepsy, its a fact, how many more studies do you need?




Seizure. 2016 Jan 6;35:41-44. doi: 10.1016/j.seizure.2016.01.004. [Epub ahead of print]


CBD-enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience.


Tzadok M1, Uliel-Siboni S2, Linder I3, Kramer U2, Epstein O4, Menascu S2, Nissenkorn A5, Yosef OB5, Hyman E4, Granot D6, Dor M7, Lerman-Sagie T3, Ben-Zeev B5.






To describe the experience of five Israeli pediatric epilepsy clinics treating children and adolescents diagnosed as having intractable epilepsy with a regimen of medical cannabis oil.



A retrospective study describing the effect of cannabidiol (CBD)-enriched medical cannabis on children with epilepsy. The cohort included 74 patients (age range 1-18 years) with intractable epilepsy resistant to >7 antiepileptic drugs. Forty-nine (66%) also failed a ketogenic diet, vagal nerve stimulator implantation, or both. They all started medical cannabis oil treatment between 2-11/2014 and were treated for at least 3 months (average 6 months). The selected formula contained CBD and tetrahydrocannabinol at a ratio of 20:1 dissolved in olive oil. The CBD dose ranged from 1 to 20mg/kg/d. Seizure frequency was assessed by parental report during clinical visits.



CBD treatment yielded a significant positive effect on seizure load. Most of the children (66/74, 89%) reported reduction in seizure frequency: 13 (18%) reported 75-100% reduction, 25 (34%) reported 50-75% reduction, 9 (12%) reported 25-50% reduction, and 19 (26%) reported <25% reduction. Five (7%) patients reported aggravation of seizures which led to CBD withdrawal. In addition, we observed improvement in behavior and alertness, language, communication, motor skills and sleep. Adverse reactions included somnolence, fatigue, gastrointestinal disturbances and irritability leading to withdrawal of cannabis use in 5 patients.




The results of this multicenter study on CBD treatment for intractable epilepsy in a population of children and adolescents are highly promising. Further prospective, well-designed clinical trials using enriched CBD medical cannabis are warranted.


Copyright © 2016 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.



CBD-enriched medical cannabis; Intractable epilepsy

CBD/THC has 89% success rate, in children that all other epilepsy medications failed to help.

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