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Michael Komorn

Oral cannabis extracts as a promising treatment for the core symptoms of autism spectrum disorder

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Oral cannabis extracts as a promising treatment for the core symptoms of autism spectrum disorder: Preliminary experience in Chilean patients


Background: Preclinical studies and several anecdotal case reports suggest a dysfunctional endocannabinoid system implicated in Autism Spectrum Disorder (ASD).

Objective: To report our preliminary findings in patients with ASD treated with oral cannabis extracts.

Patients and Methods/Material and Methods: We retrospectively reviewed all consecutive patients seen between June 2016-March 2017, with ASD diagnosis according to DSM-V, treated with sublingual whole plant cannabis extracts for at least three months. We reviewed demographic/clinical data, neuroimaging/EEG studies, vision/audition/genetic/metabolic tests, and parental/school/neuropsychological reports. Type of cannabis strain, CBD:THC ratio, daily dose of CBD/THC/CBN, and adverse events were documented. Clinical changes were estimated using Clinical Global Impression of Improvement (CGI-I) and Autism Parenting Stress Index (APSI). Informed consent was obtained.

Results: 20 children and one adult patients were selected. Mean age: 9 years, 10 months (range: 26 mo-22 yo), 15 males. Mean follow-up: 7,6 mo (range: 3-12). 66,7% of patients had significant improvement according to CGI-I and APSI. Most cases improved at least one of the core symptoms of ASD, including social communication, language, or repetitive behaviors. Additionally, sensory difficulties, food acceptance, feeding and sleep disorders, and/or seizures were improved in most cases. 71,5% of patients received balanced CBD:THC extracts; 19,0% high-CBD; and 9,5% high-THC extracts. Oral cannabis extracts were well tolerated. Two patients had more agitation and one had more irritability, effects that were solved by changing the strain.

Conclusion: In this small series of ASD patients, oral cannabis extracts were dramatically more effective than conventional medicines. Large randomized controlled trials are needed to establish efficacy and safety of medicinal cannabis in ASD.

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No if we can get our system here in michigan to recognize this treatment.

I believe my son age 8 could recieve some well needed peace from this type of treatment. The cocktail of drugs he has tried has only made things worse.

We recently had an extended eeg for him and found he was having 30+ absense seizures a day that we never saw. 

We are just scared to even talk about it with his doctors for the fear of him not being treated the same.

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    • By Michael Komorn
      Next Friday, July 31 is a very important day for the Michigan Medical Marijuana community. The MMMA, along with physicians, lawyers, and families have worked tirelessly for more than a year to add autism as a qualifying condition under the Act, and next Friday is the vote to add or deny autism into the law.
      Please attend this vote, particularly if you treat your child with marijuana, to show solidarity with the parents of autistic children and family members that have led this drive. Komorn Law has pledged to compensate food and gas for all families with children that attend.
      Just attending the panel meeting can make a huge difference, there are many people with a debilitating condition who cannot make it. If you know someone in Lansing, ask them to attend. Friday is the ideal day to show respectful support that will have a real, meaningful impact on the panel's vote, and on the futures of these parents and children in need.
      I am sure all of you can understand how important this vote is for the families who have children afflicted with autism. I personally would like to believe that with all the hoopla and attention towards legalization lately the patients and families of patients are not lost or overlooked. Medical cannabis is the real deal. For the last 6 years we have all shared together in the miracles of this plant. We have danced on this forum together making history in Michigan as we implement the 2008 voter initiative. The battle continues and the fight is scheduled for July 31. Your appearance will be a strong showing of unity of our medical cannabis community. It will help provide evidence that medical cannabis is real, and safe access for those afflicted with autistism must be the next step for the MMMA.
    • By zapatosunidos
      Michael's blog on the upcoming (July 20) Medical Marihuana Review Panel vote on autism from here:
      Was also published by the Huffington Post here:
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      "Hope is the thing with feathers
      That perches in the soul
      And sings the tune without the words
      And never stops at all."
      ― Emily Dickinson
      "You cannot swim for new horizons until you have courage to lose sight of the shore."
      ― William Faulkner
      "We dream to give ourselves hope. To stop dreaming - well, that's like saying you can never change your fate."
      ― Amy Tan, The Hundred Secret Senses
      Hope keeps us going; hope is important. It is remaining in the game, believing that things will be OK, and not giving up.
      It is getting to the end of the road, having nowhere to go, and instead of quitting, continuing to fight to figure it out, to stay present and mindful, and not give up.
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      Unfortunately it seems the lives of children and parents hang in the balance of a possibly disinterested and dysfunctional process controlled by LARA.
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      There should be no debate that those afflicted with autism are seriously ill, and the purpose of our law, and the compassion shown by Michigan voters in approval, was to protect parents, patients, and physicians. For the panel to not recommend that autism be approved as a condition of the program is to ignore their duty and responsibility.
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    • By zapatosunidos
      WHEN: Wednesday, May 27, 2015, 1:00 PM
      WHERE: Williams Building, 525 W. Ottawa St., Lansing, MI
      WHAT: Public testimony in favor of adding autism to the list of conditions which may be treated with medical marijuana.
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