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Adding Qualifying Conditions to the Michigan Medical Marihuana Act


Michael Komorn
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After the MMMA was enacted by a vote of 63% of Michigan voters in 2008, the legislature has declined to add any new qualifying conditions to protect patients from arrest.

Senator Rick Jones even attempted to remove Glaucoma from the MMMP's list of qualifying conditions. Patients , caregivers and other interested parties wrote in opposition to the bill.

A handful of petitions have been submitted over the years. LARA (and the previous MDCH department) have used various reasons and tricks to deny these petitions. Only Post Traumatic Stress Disorder has been added as a qualifying condition to the Michigan Medical Marihuana Act. Autism and Parkinson's disorder petitions were approved by the Michigan medical marihuana review board (the board consists mostly of physicians). These petitions were denied by the LARA director. The petitions were not deficient in any way and should have been accepted by LARA. We resubmitted the Autism petition again, with 20 additional research studies.

Now, with the help of numerous patients, researchers, Dwight Z. and Dr. Christian Bogner along with the Michigan Medical Marijuana Association and Michael Komorn, we have assembled a massive amount of peer-reviewed medical research and government data to show that these conditions should be approved to protect patients, caregivers and physicians from arrest for the medical use of marijuana to treat their conditions.

This project took months of work. Reading, organizing, searching and collecting thousands of pages of research from all over the world. Including the most up to date medical studies, peer-reviewed patient surveys and the national reviews of all medical marijuana studies by the National Academies of Science. The oldest peer-reviewed medical research paper cited within these petitions was from the first volume of The Lancet in 1889. Birch EA. The use of Indian hemp in the treatment of chronic chloral and chronic opium poisoning. The Lancet. 1889;133:625.

Cannabis, Indian Hemp, Marijuana, whatever you call it, physicians were using this non-toxic plant in 1889 to treat chronic opium poisoning and opium addiction. As opioid based prescriptions are addicting and killing approximately 142 Americans each day in 2017, medical marijuana is a non-lethal non-toxic way to avoid "America enduring a death toll equal to September 11th every three weeks."

The qualifying condition petitions were based primarily on the following:

Included research not only supports each qualifying condition petition, but also answers questions that the LARA directors, physicians and medical marijuana review panel board members had asked of past petitioners. Reports on dosages, safety profiles of marijuana, statistics from the CDC and Poison Control, and information from NIH, FDA and the DEA are presented in the petitions. This information was included in order to compare the safety, effects and side-effects of medical marijuana with FDA approved prescription medications.

All of the patients, caregivers, researchers, the Michigan Medical Marijuana Association and it's president Michael Komorn fully agree that marijuana should be removed from the Controlled Substances Act. Marijuana should continue to be studied as a treatment for every human and animal disease. Marijuana also should be submitted to the FDA for approval as a medicine. We fully support all clinical trials related to using marijuana as a treatment for any condition, disease or injury. As all of the scientific peer-reviewed published clinical trials show, marijuana is an effective medicine.

The http://www.nih.gov website was heavily utilized throughout this project for locating scientific peer-reviewed published research, reports and information.

The petitions are grouped by similar conditions, symptoms or mechanisms of treatment. Included in this post are some choice quotes from a few studies in each group of petitions.

001.-Anxiety.pdf
004.-depression.pdf
007.-Obsessive-compulsive-disorder.pdf
008.-panic-attacks.pdf
011.-Schizophrenia.pdf
012.-Social-Anxiety-Disorder.pdf

Marijuana and Medicine Assessing the Science Base 1999 report from the Institute of Medicine

Quote

Movement disorders are a group of neurological conditions caused by abnormalities in
the basal ganglia and their subcortical connections through the thalamus with cortical
motor areas. The brain dysfunctions ultimately result in abnormal skeletal muscle
movements in the face, limbs, and trunk. The movement disorders most often considered
for marijuana or cannabinoid therapy are dystonia, Huntington's disease, Parkinson's
disease, and Tourette's syndrome. Movement disorders are often transiently exacerbated
by stress and activity and improved by factors that reduce stress. This is of particular
interest because for many people marijuana reduces anxiety. 

https://directorsblog.nih.gov/2014/04/10/anxiety-reduction-exploring-the-role-of-cannabinoid-receptors/ 

Quote

Relief of anxiety and stress is one of the most common reasons that people give for using marijuana


Medical Cannabis in Arizona: Patient Characteristics, Perceptions, and Impressions of Medical Cannabis Legalization.

Quote

367 medical marijuana patients in Arizona were surveyed. 
181 patients reported using medical marijuana to experience relief from Anxiety
164 patients reported using medical marijuana to experience relief from Stress.
General relief from Anxiety symptoms was 82.9% and 87.2% for Stress with medical marijuana, 
Relief by medical marijuana compared to other medications was 79.3% for Anxiety and 91.6% for Stress.
Less frequent use of other medications was 85.9% for Anxiety and 79.1% for Stress.

32 patients reported using medical marijuana to experience relief from Attention-deficit/hyperactivity disorder.
General relief from ADHD symptoms was 81.2% with medical marijuana.
Relief by medical marijuana compared to other medications was 65% for ADHD.
Less frequent use of other medications was 84% for ADHD

23 patients reported using medical marijuana to experience relief from Bipolar disorder.
General relief from Bipolar disorder symptoms was 60% with medical marijuana.
Relief by medical marijuana compared to other medications was 90% for Bipolar disorder.
Less frequent use of other medications was 56% for Bipolar Disorder.

106 patients reported using medical marijuana to experience relief from Depression.
General relief from Depression symptoms was 82% with medical marijuana.
Relief by medical marijuana compared to other medications was 86.9% for Depression.
Less frequent use of other medications was 65% for Depression.

17 patients reported using medical marijuana to experience relief from Obsessive Compulsive Disorder..
General relief from OCD symptoms was 64.7% with medical marijuana.
Relief by medical marijuana compared to other medications was 62% for OCD.
Less frequent use of other medications was 33.4% for OCD.

2 patients reported using medical marijuana to experience relief from Schizophrenia.
General relief from Schizophrenia symptoms was 100% with medical marijuana.
Relief by medical marijuana compared to other medications was 100% for Schizophrenia.

28 patients reported using medical marijuana to experience relief from Post Traumatic Stress Disorder.
General relief from PTSD symptoms was 67.9% with medical marijuana.
Relief by medical marijuana compared to other medications was 92% for PTSD.
Less frequent use of other medications was 44.4% for PTSD.

 

014.-arthritis.pdf
023.-Rheumatoid-Arthritis.pdf

 

Quote
  • Arkansas lists severe arthritis as a qualifying condition.
  • California lists arthritis as a qualifying condition.
  • Connecticut lists psoriatic arthritis as a qualifying condition.
  • Illinois lists rheumatoid arthritis and Lupus as qualifying conditions.
  • Hawaii lists rheumatoid arthritis and Lupus as qualifying conditions.
  • New Hampshire lists Lupus as a qualifying condition.
  • New Mexico lists inflammatory autoimmune-mediated arthritis as a qualifying condition.

 

Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) inthe treatment of pain caused by rheumatoid arthritis

Quote

Statistically significant improvements in pain on movement, pain at rest, quality of sleep, DAS28 and the SF-MPQ pain at present component were seen following CBM ( cannabis based medicine ) in comparison with placebo.

Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis

Quote

These data indicate that topical CBD application has therapeutic potential for relief of arthritis pain-related behaviours and inflammation without evident side-effects.


025.-brain-injury.pdf
030.-Treatment-of-spinal-cord-injury.pdf

Quote

Connecticut has “damage to the nervous tissue of the spinal cord with objective neurological indication of intractable spasticity” as a qualifying condition in its medical marijuana program.

Illinois lists “Post-Concussion Syndrome”, “Spinal cord disease (including but not limited to arachnoiditis)”, “Spinal cord injury with damage to the nervous tissue of the spinal cord with objective neurological indication of intractable spasticity” and Traumatic Brain Injury as qualifying conditions in its medical marijuana program.

New Hampshire lists “spinal cord injury or disease” and traumatic brain injury as qualifying conditions in its medical marijuana program.

Ohio lists chronic traumatic encephalopathy, “spinal cord disease or injury” and traumatic brain injury as qualifying conditions in its medical marijuana program.

Pennsylvania lists “damage to the nervous tissue of the spinal cord with objective neurological indication of intractable spasticity” as a qualifying condition for its medical marijuana program.

Washington lists Traumatic brain injury as a qualifying condition for its medical marijuana program.

West Virginia lists “Damage to the nervous tissue of the spinal cord with objective neurological indication of intractable spasticity.” as a qualifying condition for its medical marijuana program.

Oregon has added “a degenerative or pervasive neurological condition” to its medical marijuana program qualifying conditions. 


031.-asthma.pdf
 

Effects of smoked marijuana in experimentally induced asthma.

Quote

After experimental induction of acute bronchospasm in 8 subjects with clinically stable bronchial asthma, effects of 500 mg of smoked marijuana (2.0 per cent delta9-tetrahydrocannabinol) on specific airway conductance and thoracic gas volume were compared with those of 500 mg of smoked placebo marijuana (0.0 per cent delta9-tetrahydrocannabinol), 0.25 ml of aerosolized saline, and 0.25 ml of aerosolized isoproterenol (1,250 mug). After exercise-induced bronchospasm, placebo marijuana and saline were followed by gradual recovery during 30 to 60 min, whereas 2.0 per cent marijuana and isoproterenol caused an immediate reversal of exercise-induced asthma and hyperinflation.

Our present findings and those previously reported demonstrated acute airway dilatation after smoked marijuana.

Effects of cannabis on lung function: a population-based cohort study

Quote

Cumulative cannabis use was associated with higher forced vital capacity, total lung capacity, functional residual capacity and residual volume. Cannabis was also associated with higher airway resistance but not with forced expiratory volume in 1 s, forced expiratory ratio or transfer factor. These findings were similar among those who did not smoke tobacco

Newspaper ad from 1876 selling marijuana cigarettes for treating asthma.

asthma-cigarettes.jpg

You may laugh at a marijuana cigarette as a real medical treatment, but marijuana is a verified bronchodilator similar in strength to albuterol, the standard asthma medication. The medical efficacy of this specific brand of Asthma cigarettes were specifically exempted within the Single Convention on Narcotic Drugs as created by the United Nations. This means these marijuana cigarettes were still able to be sold after each country banned marijuana.

https://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1951-01-01_4_page002.html

Quote

PREPARATIONS NOTIFIED AS EXEMPTED FROM NARCOTIC CONTROL

5. Indian Cigarettes of Grimault (Dr. Ph. Chapelle) C.L.302.1930.III. Annex I.
Government: Siam
Ingredients:
Belladonna leaves - 0.962 gm
Cannabis indica extract - 0.0005 gm.
Nitrate of potash - 0.033 gm.

https://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1962-01-01_4_page005.html

Quote

Preparations made from the extract and tincture which are capable only of external use, and a medicinal cigarette called "Indian Cigarettes of Grimault" (Dr. P. H. Chapelle) are exempted from control.

036.-diabetes.pdf
 

The Health Effects of Cannabis and Cannabinoids The Current State of Evidence and Recommendations for Research (2017)

Quote

Counterintuitively, the majority of the reviewed studies showed that cannabis was associated with a lower BMI or a lower prevalence of obesity, or both (Hayatbakhsh et al., 2010; Le Strat and Le Foll, 2011; Smit and Crespo, 2001; Warren et al., 2005), or to have no association with BMI or obesity (Rodondi et al., 2006).

The Impact of Marijuana Use on Glucose, Insulin, and Insulin Resistance among US Adults

Quote

In this large, cross-sectional study, we found that subjects who reported using marijuana in the past month had lower levels of fasting insulin and HOMA-IR, as well as smaller waist circumference and higher levels of HDL-C. These associations were attenuated among those who reported using marijuana at least once, but not in the past 30 days, suggesting that the impact of marijuana use on insulin and insulin resistance exists during periods of recent use.

In the present study, we demonstrate a significant association between current marijuana use and lower levels of fasting insulin and insulin resistance in multivariable adjusted analyses even after excluding participants with prevalent diabetes mellitus.

With the recent trends in legalization of marijuana in the United States, it is likely that physicians will increasingly encounter patients who use marijuana and should therefore be aware of the effects it can have on common disease processes, such as diabetes mellitus. We found that current marijuana use is associated with lower levels of fasting insulin, lower HOMA-IR, and smaller waist circumference.

044.-colitis.pdf
050.-gastric-ulcer.pdf
055.-Inflammatory-bowel-disease-IBD.pdf
064.-Ulcerative-colitis.pdf

Marijuana Use Patterns Among Patients with Inflammatory Bowel Disease

Quote

Our findings suggest that patients with UC may also benefit from the use of medicinal marijuana although the 11 states that have legalized medical marijuana have only approved its use for only patients with CD. Lawmakers should consider adding this condition to the list of acceptable diseases that may be treated with medicinal marijuana.

Minnesota Medical Cannabis Program: Patient Experiences from the First Program Year by the MN Department of Health 2016.

Quote

Number of liquid/soft stools per day decreased by ≥30% for 51.2% of patients with at least five liquid/soft stools per day at baseline. Among patients who achieved ≥30% reduction, 57% (29.3% of patients included in analysis at baseline) retained that level of improvement over the next four months.

Severity of abdominal pain improved for 53.4% of patients with moderate or severe abdominal pain at baseline. Among patients who reported an improvement in abdominal pain, 36% (19.2% of patients included in analysis at baseline) retained that improvement over the next four months.

General well-being improved for 46.7% of patients who described their baseline well-being as “Very Poor” or “Terrible” at baseline. Among patients who reported an improvement in general well-being, 29% (13.3% of patients included in analysis at baseline) retained that improvement over the next four months.

On the combined Crohn’s activity measure (number of liquid/soft stools, abdominal pain, general well-being), 51.0% of Crohn’s Disease patients achieved ≥30% improvement. Among patients who achieved ≥30% reduction, 42% (21.6% of patients included in analysis at baseline) retained that level of improvement over the next four months. An increase of at least 3% in body weight was reported by 20.6% of patients. Among the patients who achieved ≥3% increase in body weight, 57% (11.8% of patients included in analysis at baseline) retained that increase over the next four months.

Cannabinoids and the Urinary Bladder

Quote

To date, a small number of open-label and placebo-controlled studies have demonstrated that oral administration of cannabinoids may alleviate OAB/DO symptoms as first line. Most of these studies have been carried out on patients with advanced multiple sclerosis using preparations containing Δ9 -THC and/or CBD. One such study using Sativex, showed a reduction in urgency, number of incontinence episodes, frequency and nocturia in patients with multiple sclerosis.

Cannabinoids and gastrointestinal motility: Animal and human studies

Quote

The plant Cannabis has been known for centuries to be beneficial in a variety of gastrointestinal diseases, including emesis, diarrhea, inflammatory bowel disease and intestinal pain.

Medical cannabis – the Canadian perspective

Quote

Case Report

The patient was prescribed 1 g per day of a cannabis strain containing 9% THC and 13% CBD to be administered by a vaporizer. At 60 days of follow-up, the patient’s pain was lowered to a weekly average of 3/10 on a numerical rating scale. The patient also indicated he did not see a need for pregabalin, and had begun the process of lowering his daily dose. Surprisingly, the patient also reported far fewer symptoms of his irritable bowel syndrome, claiming near-remission.

Impact of cannabis treatment on the quality of life, weight and clinical disease activity in inflammatory bowel disease patients: a pilot prospective study.

Quote

Thirteen patients were included. After 3 months' treatment, patients reported improvement in general health perception, social functioning, ability to work , physical pain  and depression. A schematic scale of health perception showed an improved score. Patients had a weight gain of 4.3 ± 2 kg during treatment and an average rise in BMI of 1.4 . The average Harvey-Bradshaw index was reduced.

CONCLUSIONS:

Three months' treatment with inhaled cannabis improves quality of life measurements, disease activity index, and causes weight gain and rise in BMI in long-standing IBD patients.



106.-organ-transplant.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541500/

Quote

Together, the current study shows, for the first time to our knowledge, that the CB-ligand system may have a critical role in allograft rejection. THC treatment reduced the T cell response in the host by dampening the secretion of proinflammatory cytokines and expression of T cell activation markers. Additionally, THC treatment resulted in delayed graft destruction, even in a MHC disparity model of allogenic skin transplant. Induction of highly immunosuppressive MDSCs following THC treatment proved to be necessary, at least in part, for THC-mediated attenuation of allograft rejection. We also noted that this effect of THC was dependent on activation of CB1 rather than CB2. The current study sets the stage for additional studies on the cannabinoid system in regulating transplant rejection involving potential manipulation of endocannabinoids, receptors, and the use of CB-select agonists that are not psychoactive.

Medical Marijuana and Organ Transplantation: Drug of Abuse, or Medical Necessity?

Quote

The case was in the evening news a few days later and generated much press coverage. Despite this, the transplant team held firm even when other physicians advocated for the patient and noted that there was no scientific literature showing any increased risk of organ damage or rejection from someone using marijuana. Tragically, the patient died of liver failure 3 weeks later, leaving behind his wife and 2 children, ages 8 and 12. In the actual case, the ethics team was never consulted or even formally made aware of this case. This patient was following the state law, allowing him to use marijuana to treat his pain, nausea, and vomiting, which turned out to be the only thing that worked. Despite following state laws, this state funded university hospital turned him down for a liver transplant.


107.-Non-severe-and-non-chronic-Pain.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998228/

Quote

In order to discover the benefits and adverse effects perceived by medical cannabis patients, especially with regards to chronic pain, we hand-delivered surveys to one hundred consecutive patients who were returning for yearly re-certification for medical cannabis use in Hawai‘i.

The response rate was 94%. Mean and median ages were 49.3 and 51 years respectively. Ninety-seven per cent of respondents used cannabis primarily for chronic pain. Average pain improvement on a 0–10 pain scale was 5.0 (from 7.8 to 2.8), which translates to a 64% relative decrease in average pain. Half of all respondents also noted relief from stress/anxiety, and nearly half (45%) reported relief from insomnia. Most patients (71%) reported no adverse effects, while 6% reported a cough or throat irritation and 5% feared arrest even though medical cannabis is legal in Hawai‘i. No serious adverse effects were reported.

These results suggest that Cannabis is an extremely safe and effective medication for many chronic pain patients. Cannabis appears to alleviate pain, insomnia, and may be helpful in relieving anxiety. Cannabis has shown extreme promise in the treatment of numerous medical problems and deserves to be released from the current Schedule I federal prohibition against research and prescription.

LARA statistics show the majority of the 250,000+ patients in the MMMA are using cannabis to treat chronic pain. As we know that the medical use of marijuana can treat “severe and chronic pain” already, it can and should be used to treat regular generic pain that is not severe and chronic.

Quote

Severe and Chronic pain 79.99%

Severe and Chronic pain 92.77%

The reports and information from the Minnesota Department of Health on its medical marijuana program are very detailed and informative about patients experiences with medical marijuana.

Minnesota Medical Cannabis Program: Patient Experiences from the First Program Year by the MN Department of Health 2016.

http://www.health.state.mn.us/topics/cannabis/about/appendixa.pdf

Quote
  • it works quickly to relieve muscle spasms,,helps control pain during physical work, controls pain to a certain extent, helps give you opportunity to quality of life.
  •  [PATIENT]’s mobility has increased.
  •  some pain relief
  •  Less lower back pain, increased apatite.
  •  Less muscle aches and better sleep.
  •  Less muscle spasm's = body not being as fatigued allowing me to perform my physical therapy better.
  •  Less muscle spasms!!
  •  less mussel spasms and pain
  •  less nerve pain
  •  Less pain and inflammation in legs and ankles. Didn't feel so wore out at the end of the day. Was able to relax and sit for long periods with less stiffness and joint pain. Overall I had less pain
  •  Less Pain
  • Less sleep issues
  • More hunger'
  • Less mood swings
  • All around better feeling of life
  •  less petit mal seizures , better sleep at night and , reduced muscles pasms
  •  less seizures
  •  Less spasms helps me relax.
  •  Many fewer spasms. I went from several per hour every day to several per day. Much improvement! I also have less anxiety. My confidence has increased from feeling more relaxed.
  •  Much less pain, in my bowel and neurapathy pain. I can tell almost immediately if I forget to take the medication. Within one or two hours, the pain in the gut/bowel area is back. I never realized how terrible I have felt until after I started to feel better. I have had bowel pain as long as I can remember (pre-school) and I thought everyone felt like that. It is all I ever knew and it was getting worse eachyear.
  •  much less weakness/pain
  • easier sleeping
  • not as many spasms in the morning

108.-Parkinsons.pdf

Other states already approve of medical marijuana for Parkinson's Disease.

Including: Georgia, Vermont, Connecticut, Florida, Illinois, Massachusetts, New Hampshire, Ohio, New Mexico, New York, Pennsylvania, West Virginia and California

http://www.google.com/patents/US6630507 

Quote

Original Assignee

The United States Of America As Represented By The Department Of Health And Human Services

The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia.

As used herein, a “cannabinoid” is a chemical compound (such as cannabinol, THC or cannabidiol) that is found in the plant species Cannabis sativa (marijuana)



111.-Tourette's-Syndromequalifying.pdf

Tourette’s Syndrome is an approved medical marijuana qualifying condition in Arkansas, Illinois, Minnesota and Ohio. While the MMMA covers persistant and severe Muscle Spasms, Tourette's Syndrome sufferers may not have the severe symptoms that qualify.

The 1999 Institute of Medicine report states that marijuana can be used to treat Tourettes
Syndrome.

Quote

Neurological disorders affect the brain, spinal cord, or peripheral nerves and muscles in
the body. Marijuana has been proposed most often as a source of relief for three general
types of neurological disorders: muscle spasticity, particularly in multiple sclerosis
patients and spinal cord injury victims; movement disorders, such as Parkinson's
disease, Huntington's disease, and Tourette's syndrome; and epilepsy. Marijuana is not
proposed as a cure for such disorders, but it might relieve some associated symptoms.

Clinical reports consist of four case histories indicating that marijuana use can reduce
tics in Tourette's patients. In three of the four cases the investigators suggest that
beneficial effects of marijuana might have been due to anxiety-reducing properties of
marijuana rather than to a specific anti tic effect.


112.-MMRP-Autism-Petition-2qualifying.pdf

Pennsylvania Medical Marijuana Program lists Autism as a qualifying condition.

There are two clinical trials for Autism and cannabis in 2017:

Cannabinoids for Behavioral Problems in Autism Spectrum Disorder: A Double Blind, Randomized, Placebo-controlled Trial With Crossover.

Quote

Detailed Description:

Disruptive behaviors are very common in children and youth with autism spectrum disorder (ASD). Behavioral problems increase social impairment in children with ASD, make interventions more difficult and place considerable strain on families and caregivers. Current treatment is based on behavioral interventions combined with atypical antipsychotics which often have low tolerability and questionable efficacy.

Cannabis exerts profound effects on human social behavior. Research using animal models of ASD indicate a possible dysregulation of the endocannabinoid system, and stress that it may be a novel target for pharmacological interventions. Anecdotal evidence suggest efficacy of various phytocannabinoids in resistant behavioral problems. However controlled human studies are lacking.

Objective: To assess the safety, tolerability and efficacy of cannabinoids mix [cannabidiol (CBD), Δ9-tetrahydrocannabinol (THC) in a 20:1 ratio] for behavioral problems in children and youth with ASD.

Setting: A double blind randomized placebo-controlled trial with crossover. Methods: One hundred and twenty participants ages 6-30 years, with established ASD diagnosis and moderate to severe refractory behavioral problems will be treated with placebo and cannabinoids mix in a randomized cross-over trial. Each intervention period will be 12 weeks with additional 4 weeks for gradual dose decrease and wash-out. Baseline evaluations will include: Autism diagnostic observation schedule (ADOS-2), Social Communication Questionnaire (SCQ), Vineland II (interview based), Childhood Autism Rating Scale (CARS-2, observation based). Primary outcome measures: Home Situations Questionnaire-Autism Spectrum Disorder (HSQ-ASD), Child Behavior Checklist (CBCL, parent-rated), and Autism Parenting Stress Index (APSI) will be assessed every 4 weeks. Secondary outcome measures: Clinical Global Impression (CGI, improvement and efficacy index items, clinician-rated) and Social Responsiveness Scale (SRS, parent and teacher rated) will be assessed at baseline and termination of each treatment period. Adverse events will be taped every 4 weeks.

Cannabidivarin (CBDV) vs. Placebo in Children With Autism Spectrum Disorder (ASD)

Quote

Sponsor:

Montefiore Medical Center

Collaborator:

United States Department of Defense

Study Description

This trial aims to study the efficacy and safety of cannabidivarin (CBDV) in children with ASD. 

Study Type  :    Interventional  (Clinical Trial)
Estimated Enrollment  :    100 participants
Allocation:    Randomized
Intervention Model:    Parallel Assignment
Intervention Model Description:    Phase 2, 12-week double-blind, randomized, placebo-controlled trial
Masking:    Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Masking Description:    Double-Blind
Primary Purpose:    Treatment

https://nccih.nih.gov/health/autism

Quote

Marijuana hasn’t been studied for ASD, though there’s interest in its use by some patient groups to help with behavioral symptoms associated with ASD. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473390/

Quote

Behavioral Conditions. Cannabinoids and CBD use in this patient population is a growing interest on social media sites. While the data for these indications are limited to case reports using dronabinol, some of the benefits of CBD on behavior and motor skills reported in the aforementioned retrospective studies in epilepsy may be transferable to this population as well. A 6-year-old patient with early infant autism received enteral dronabinol drops titrated up to 3.62 mg/day. He had improvements in hyperactivity, irritability, lethargy, stereotype, and speech.41 In a published abstract, Kruger et al42 report on the effect of dronabinol use in treating self-injurious behavior in 10 mentally retarded adolescents. The dronabinol dose ranged from 2.5 mg twice daily to 5 mg 4 times a day. Seven of the 10 patients had significant improvement in their self-injurious behavior that lasted through the follow-up at 6 months. Two of the 10 patients experienced agitation and the drug was discontinued. An Israeli single-center, double-blind, placebo-controlled cross-over trial of CBD and THC in a 20:1 mixture for behavioral problems in children with autistic spectrum disorder is scheduled to start in January 2017.43

Safety and Efficacy of Medical Cannabis Oil for Behavioral and Psychological Symptoms of Dementia: An-Open Label, Add-On, Pilot Study.

Quote

RESULTS:

Ten patients completed the trial. Significant reduction in CGI severity score (6.5 to 5.7; p <  0.01) and NPI score were recorded (44.4 to 12.8; p <  0.01). NPI domains of significant decrease were: Delusions, agitation/aggression, irritability, apathy, sleep and caregiver distress.

CONCLUSION:

Adding Medical Cannabis Oil to Alzheimer’s disease patients' pharmacotherapy is safe and a promising treatment option.

An Open Label Study of the Use of Dronabinol (Marinol) in the Management of Treatment-Resistant Self-Injurious Behavior in 10 Retarded Adolescent Patients

Quote

Conclusions: In a series of patients who presented with treatment-
resistant self-injurious behavior, eight of the 10 showed an improvement
in their behavior when treated with Marinol without serious enough side
effects to merit discontinuing the medication. At 6 month follow-up,
seven of the 10 continued to benefit from the Marinol, and the eighth
patient had discontinued the medicine due to a change in her living
situation. The tolerability of Marinol in this study is consistent with the
experience of Lorenz (2004) whose patients presented with a variety of neurological disorders but not specifically SIB.

 

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648553/

Quote

Anecdotal reports continue to emerge of children with intractable epilepsy and severe autism who show symptomatic improvement after being administered cannabinoids. The call from the public for research on cannabinoids is growing louder and many families are already using marijuana for childhood conditions – this despite very little evidence on efficacy and in the face of known long-term harms. The medical community has an urgent duty to respond. As we face a tide of rapidly changing attitudes and policies on marijuana in the US and elsewhere, it is urgent that we prioritize carefully conducted RCTs to close the current knowledge gap.

 

 

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      The opinions and comments expressed on the show by hosts, guest, commentators, posts, articles, etc... may or may not represent the actual opinions or thoughts of the Komorn Law Firm and/or it's associates. The thoughts and conversation that occur during this broadcast are an attempt to bring humor and parody to an otherwise non comical scenario. Although some conversations and guests may state facts, academic impedimenta and scientific theorems one should consult an attorney or expert in the relevant field of query.
       
       
    • By T2Tone
      PLANET GREEN TREES TV - Episode 485
      Episode Title – Steady As She Goes
      Episode Date – 10-08-20
      On This Episode Topics (no particular order)
      1. Michael’s Rant
      2. CANNABIS BUSINESS LICENSE APPLICATIONS BEING ACCEPTED EARLY
      3. Ann Arbor, Michigan, decriminalizes magic mushrooms, psychedelic plants
      4. Federal Workplace Drug Testing Proposal Could Discriminate Against People of Color
      5. CDC Meets with Medical Marijuana Patients to Discuss Cannabis as an Alternative Pain Therapy
      6. Cannabis Life Advice: When is it time to smoke less weed?
      Show Information
      -Michigan's #1 show about cannabis legal issues, licensing, regulations, compliance, medical marijuana topics, current events and other legal matters. -Planet Green Trees TV is hosted by Attorney Michael Komorn, co-hosted by Jim Powers, Amanda Joslin, Alyssa McCormick and Jamie Lowell
      LINKS Can Be Found Here - https://PlanetGreenTreesTV.com PLANET GREEN TREES TV -
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      Disclaimer
      The opinions and comments expressed on the show by hosts, guest, commentators, posts, articles, etc... may or may not represent the actual opinions or thoughts of the Komorn Law Firm and/or it's associates. The thoughts and conversation that occur during this broadcast are an attempt to bring humor and parody to an otherwise non comical scenario. Although some conversations and guests may state facts, academic impedimenta and scientific theorems one should consult an attorney or expert in the relevant field of query.
       
       
    • By T2Tone
      PLANET GREEN TREES TV - Episode 487 Title - The Great Debate
      Date – 10-22-20
      Most Likely...ON THIS EPISODE
      Open season on the microphone while we monitor the presidential debate and make observations. Maybe... 
      1. Michael’s Rant
      2. Lawmakers, police, governor warned in May about armed militia, threats
      3. Supreme Court Declines to Hear Marijuana Case Challenging DEA’s Restrictive Classification
      4. Om of Medicine employees allege toxic workplace environment
      5. Where recreational marijuana is legal, data show minimal impacts on teen use and traffic deaths
      6. Senate Bill 858 - Introduced by Senator BARRETT - A bill to amend 1976 PA 390, entitled "Emergency management act,"
      Show Information
      -Michigan's #1 show about cannabis legal issues, licensing, regulations, compliance, medical marijuana topics, current events and other legal matters.
      -Planet Green Trees TV is hosted by Attorney Michael Komorn, co-hosted by Jamie Lowell, Alyssa McCormick, Jim Powers and Amanda Joslin
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      #KomornLaw #PlanetGreenTreesTV #MichiganMedicalMarijuana #MMMA #CreativeRec #TegridyLaw
      Disclaimer
      The opinions and comments expressed on the show by hosts, guest, commentators, posts, articles, etc... may or may not represent the actual opinions or thoughts of the Komorn Law Firm and/or it's associates. The thoughts and conversation that occur during this broadcast are an attempt to bring humor and parody to an otherwise non comical scenario. Although some conversations and guests may state facts, academic impedimenta and scientific theorems one should consult an attorney or expert in the relevant field of query.
    • By Michael Komorn
      Pregnancy and Medical Marijuana
      Expectant mothers are searching for answers about the safety profile of Medical Marijuana. Unfortunately the scientific community has dropped the ball and kicked it off the cliff on this issue. The lack of scientific research is due to marijuana’s illegality. Further, there exist huge biases within the published research. Mostly the research confounds marijuana use with tobacco and/or alcohol, two known causes of fetus and child harm. Separating out marijuana effects from the self-reported research on mothers who also smoke tobacco and drink alcohol is impossible. Likewise no pregnant women are signing up for research studies due to the illegality of marijuana and CPS removing children from mothers for testing positive for marijuana use.
      Many organizations quote from other organizations, who quote from other studies and reviews. The Minnesota Department of Health OFFICE OF MEDICAL CANNABIS quotes from the American College of Obstetricians and Gynecologists Committee report:
      In the American College of Obstetricians and Gynecologists official committee opinion, interim update Oct 2017, the committee found:
       
       
      Uninformed opinion, with zero evidence and lots of fear, uncertainty and doubt (FUD) are used to scare mothers away from a nontoxic plant. These uninformed unscientific opinions are being used by lawmakers to craft laws continuing the cycle of FUD and the illegality of marijuana. “Oh we don’t know what marijuana does, so let’s treat it like heroin” and “if anyone questions our opinion of marijuana, we’ll call them dirty lazy pothead stoner hippies” or “puppets of the marijuana industry”.
       
      But we do know what marijuana does. One cannot live in a bubble and ignore reality and the world around us. Women smoke and eat marijuana while pregnant.
      Cannabis use during pregnancy in France in 2010
      Trends in Self-reported and Biochemically Tested Marijuana Use Among Pregnant Females in California From 2009-2016

      http://news.gallup.com/poll/194195/adults-say-smoke-marijuana.aspx 
       
      Much of the opinions on marijuana are tainted by a small number of poorly designed studies on marijuana. For example, the National Institute of Health gives grants to researchers through NIDA, the National Institute of Drug Abuse, to study marijuana. NIDA’s focus is on drug abuse, so 90% of its grants are for studies on marijuana abuse, not marijuana benefits. When you ignore half of your research, you ignore science. Many of these studies are completed in order to get future grants from NIDA; research is often conducted from the conclusion backwards in order to show some kind of harm from marijuana use. This, in of itself, does not bias research.
       
      https://www.nytimes.com/2010/01/19/health/policy/19marijuana.html 
       
      The bias is introduced when researchers are rushed and forced to publish results, even if the studies were deficient. For example, every website and newspaper ran with the story about marijuana using children lose IQ points. Not many reported on the follow-up study that could not replicate the first study. When eliminating co-founders, the new study found no drop in IQ points. Further, research on twin siblings showed that the drop in IQ was due to parenting, binge drinking or other societal influences, not marijuana.
      https://www.drugabuse.gov/news-events/nida-notes/2016/08/study-questions-role-marijuana-in-teen-users-iq-decline 

       
      Try reading that last sentence again. In a world of science, evidence, reasoning and logic, a doctor makes a statement that decades of use of marijuana might make you lose intellectual function, based on conjecture.
      NIDA also continues to perpetuate the myth that Marijuana is a “gateway drug”.
      https://www.drugabuse.gov/publications/research-reports/marijuana/marijuana-gateway-drug 
      These findings are consistent with the idea of marijuana as a "gateway drug." However, the majority of people who use marijuana do not go on to use other, "harder" substances.
      NIDA, NIH, FDA, DEA, including other federal, state, and local government organizations and private companies continue to perpetuate these and other lies in order to keep marijuana illegal. ASA has filed complaints against the DEA multiple times to get it to remove incorrect statements about marijuana off of the DEA’s website.
      http://www.safeaccessnow.org/iqa_victory 
      A cyclical pattern emerges from the current and past situation surrounding marijuana.
      1.      Stymied scientific research, due to illegality of marijuana and government funding biases
      2.      Using stymied scientific research as a reason to ignore reality.
      3.      Repeating the biased scientific research, long after it was shown to be deficient.
      4.      Using the deficient biased research in “meta-reviews”. Thus taking bad science as a base to create more bad science just by doing an analysis of the bad science conclusions.
      5.      Even after a research study has been fully proven to be deficient and conflicting with better research, continue to hold it up as if it is still valid in some way.
      6.      Publish opinions as if they were facts, without any data to back up any claims.
      Continue reading for more conflicting studies and more calls for research.
      Marijuana: Prenatal and Postnatal Exposure in the Human
      Marijuana use in pregnancy and lactation: a review of the evidence
       
      Marijuana and Pregnancy
      The Association of Marijuana Use with Outcome of Pregnancy
       
      Prenatal Tobacco, Marijuana, Stimulant, and Opiate Exposure: Outcomes and Practice Implications 
      Many of these studies contradict themselves. Some report differences in birth weight, some show no differences. Read the studies yourself!
       
      http://legislature.mi.gov/doc.aspx?2017-HB-5222 
      House bill 5422 will force MMFLA provisioning centers to give patients and caregivers an unscientific pamphlet, as described by the legislature.
       
       
      HB 5222 looks like it will pass. All this fear and doubt of a non-toxic 5,000+ year old medication used by millions of humans in every country in the world.
    • By Michael Komorn
      Hemp, Inc. (OTC: HEMP), the first all-hemp, publicly-traded company in US history forges path in the industrial hemp industry, continues its effort to blow the lid off a nest of deception and double standards many feel have been imposed by the United States government concerning the ancient superfood, hemp seeds. Despite the Cannabis classification, hemp seeds aren't for smoking, nor does it get you "high" as countless people have been led to believe, according to the Kimble Group, LLC. Hemp seeds are growing in popularity, thus, questions are arising concerning their presumed health benefits. So what is it 'they' don't want the American people to know? Why would such enlightening, useful and beneficial information be kept under wraps?
      http://www.prweb.com/releases/hemp/marijuana/prweb9954724.htm
       
       
       
      The first all-hemp, publically-traded company in US History,Hemp, Inc. (OTC: HEMP), hemp.com, blows the lid off a nest of deception.
      (PRWEB) September 28, 2012
       
      It wasn't until this year, August, US senators Jeff Merkley, Ron Wyden, Bernie Sanders and Rand Paul ardently worked together in a bipartisan effort to get industrial hemp removed from the federal doghouse. If passed, this historic senate bill will create economic opportunities by removing federal restrictions on the domestic cultivation of industrial hemp.
      Before light is shed on the benefits on hemp, let's take a look at how and why hemp has been getting a bad rap over the years. According to Hemp, Inc. (OTC: HEMP), the first all-hemp, publically-traded company in US history, William Hurst, an influential American newspaper publisher, created a yellow journalism campaign to associate hemp with marijuana. Why?
      Commercial hemp seeds contain very low amounts of THC, the property responsible for the drug response, plus they contain a substance that counteracts THC. According to Dr. David P. West, who specializes in plant breeding and genetics and who has written a plethora of articles on industrial hemp, says, "The washed hemp seed contains no THC at all. The tiny amounts of THC contained in industrial hemp are in the glands of the plant itself. Sometimes, in the manufacturing process, some THC- and CBD-containing resin sticks to the seed, resulting in traces of THC in the oil that is produced. The concentration of these cannabinoids in the oil is infinitesimal. No one can get high from it."
      Hurst, along with his friend Pierre DuPont, succeeded in outlawing hemp in America and in turn robbed the world of an environmental cash crop. Why would they do such a thing? As noted by Hemp.com, "Because instead of using hemp for paper, clothing, fuel, oils, resins, medicines, and many other uses, we now use trees and synthetic petrochemicals. Hearst owned huge forests and interests in lumber mills. DuPont made synthetic fuels and fibers (nylon, rayon, plastics) from petroleum." Go figure.
      Hemp seeds go back as far as 8,500 years. Initially, the Chinese were harvesting it and using the plant fibers to produce durable cloth, however, 3,000 years ago, they began using the seeds as a food source. Hemp seeds have been a proven source of protein on the planet, primarily because they contain all twenty one known amino acids.
      Clinical herbalist, Larken Bunce, says, "Hemp seeds are a nutritionally dense food source that provide the body with necessary macro- and micronutrients, including protein, essential fatty acids, fiber, vitamins and minerals. The addition of hemp seeds to your daily diet can ensure you are getting necessary essential fatty acids, a good balance of protein and carbohydrates, a good source of fiber as well as some essential vitamins and minerals."
      Essentially, the human organism is unable to produce all essential amino acids, but amazingly, hemp does. The hemp seeds are a great source of polyunsaturated fat as well as essential fatty acids. According to Nourishing Gourmet, hemp foods are also a rich source of phytonutrients, the organic compounds of plants that are thought to promote human health.
      More specifically, Dr. Cassandra Forsyth, nutrition researcher at the University of Connecticut, says, "Hemp seeds are rich in omega3 fatty acids, which reduce your risk of heart disease and stroke." According to an article in Men's Health, written by Carolyn Kylstra on 9/25/12, a 1-ounce serving of the seeds provides 11 grams of protein, not to be confused with incomplete protein found in most plant sources. The article's research found the protein in hemp seeds to be comparable to that found in meat, eggs, and dairy.
      If hemp food is easily digested and in turn can be used to treat malnourishment, why such a bad rap? Why not mass produce since the consumption of complete proteins is necessary for human survival? The US Government's complacency of 'profit before health' can no longer stand on the incredulous foundation on which it was built. The American people are, indeed, waking up.
       
      Michael A. Komorn
      Attorney and Counselor
       
      Email: michael@komornlaw.com
      Website: www.komornlaw.com
       
      Check out our Radio show:
      http://www.blogtalkradio.com/planetgreentrees
       
      Live Every Thursday 8-10:00p.m.
       
      PLANET GREENTREES
      w/ Attorney Michael Komorn
       
      The most relevant radio talk show for the Michigan Medical Marijuana Community. PERIOD


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