CBD Is Everywhere, but Scientists Still Don’t Know Much About It

[zeebudz]

From the NY Times: https://www.nytimes.com/2019/02/25/well/live/cbd-cannabidiol-marijuana-medical-treatment-therapy.html

A coupe of snippets:

Quote

Cannabidiol, or CBD, a nonintoxicating component of the marijuana plant, is touted as a magic bullet that eases pain, anxiety, insomnia and depression. Salves, sprays, tinctures and oils containing CBD are marketed as aphrodisiacs that boost desire; as balms for eczema, pimples and hot flashes; and even as treatments for serious diseases like diabetes and multiple sclerosis.

Unlike THC, or tetrahydrocannabinol, the “psychoactive” component of the cannabis plant, CBD won’t get you “high.” But scientists know little about what it can do: Most of the information about CBD’s effects in humans is anecdotal or extrapolated from animal studies, and few rigorous trials have been conducted.

“It is a kind of a new snake oil in the sense that there are a lot of claims and not so much evidence,” said Dustin Lee, an assistant professor in psychiatry and behavioral sciences at Johns Hopkins University who is planning a human trial of CBD for use in quitting smoking.

Quote

One Israeli trial found that people with Crohn’s disease improved when they used cannabis, but a randomized controlled trial of CBD alone found no benefit for patients with treatment-resistant Crohn’s, though investigators said the dose used may have been too low to be effective.

Indeed, CBD research is at such an early stage that just figuring out the correct therapeutic dose to test is a challenge, scientists say.

Scientists are anticipating easier access to the drug for research since a bill signed late last year removed hemp-derived products like CBD from the list of Schedule 1 controlled substances , and allowed for the cultivation of hemp, which is defined as having less than 0.3 percent THC content. Before passage of that bill, CBD was considered part of the marijuana plant, and researchers in the U.S. were required to have a license in order to possess it, and had to obtain the product from a government-approved source and keep it under lock and key.

Still, procuring high quality, uncontaminated CBD for research remains a daunting task, said Dr Lee. of Johns Hopkins.

“It might be available at the local 7-11 in Pennsylvania,” said Dr. Lee “but any product you get on the market is not federally regulated by the F.D.A, so the purity and safety and quality are questionable.”

Indeed, a recent study that evaluated dozens of CBD products ordered online found that nearly 70 percent were not labeled accurately and had either higher or lower concentrations of the ingredient than indicated on the label. Some also contained THC.

 

[Restorium2]

It wasn't that the CBD dose was too low, it was that there was no THC. Low dose THC is the key to CBD usefulness.

If you combine the two you don't need a high dose of either. 

[Restorium2]

The mindset seems to be that if someone can split up CBD and THC, make that work, then they could really cash in. 

Human Nature; When there's no money to be made building then we will make money off of tearing it apart.

On top of that they would have the bonus of consoling the THC haters.

On top of that they could make something that not many can make on their own. Exclusiveness makes money while helping only those with a fat wallet. 

All the answers go towards inclusiveness when it comes to cannabis. What a wonderful thing!

 

[zeebudz]

22 hours ago, Restorium2 said:

The mindset seems to be that if someone can split up CBD and THC, make that work, then they could really cash in. 

Human Nature; When there's no money to be made building then we will make money off of tearing it apart.

On top of that they would have the bonus of consoling the THC haters.

On top of that they could make something that not many can make on their own. Exclusiveness makes money while helping only those with a fat wallet. 

All the answers go towards inclusiveness when it comes to cannabis. What a wonderful thing!

 

Yep, and here is the latest on  that attempt:

FORGET GROWING WEED—MAKE YEAST SPIT OUT CBD AND THC INSTEAD

https://www.wired.com/story/yeast-cbd-and-thc/

[Restorium2]

Imagine the terpenes and flavonoids off of that nasty yeast. 

[hoyshirmr]

This is a very interesting topic. I've wanted to read about it for a long time.