Scientist Reports Finding New Compound In Jamaican Ganja

[Wild Bill]

Scientist reports finding new compound in Jamaican ganja

Monday, January 27, 2014

 

LOCAL scientist Hawthorne Watson says he has isolated a new chemical compound from ganja, but is yet to determine whether it has any medicinal value.

 

Watson named the chemical compound as Cannabitriol (CBT), and said that while clinical studies have not yet been initiated... "its structure gives reasons to be upbeat".

 

"CBT has essentially the same basic structure as Tetrahyrocannabinol (THC), which is the main psychoactive compound found in ganja and is primarily responsible for giving the 'high'," Watson wrote in an article submitted to the Jamaica Observer.

 

"CBT, however, has two additional alcoholic groups," Watson said. "In addition, the position of what in Chemistry is called a 'double bond' is different. Interestingly, there are two different forms of THC and two different forms of CBT; but the reasons for their existence are widely unrelated."

 

Watson's findings come amidst growing debate in Jamaica and other countries about the medicinal use of ganja, also known as marijuana.

 

On January 8, the health ministry in France approved commercial sales of Sativex, a medicine derived from cannabis, for the first time.

 

Sativex, produced by Britain's GW Pharmaceuticals, will be allowed for the treatment of muscle spasms associated with multiple sclerosis.

 

Locally, legislators have been encouraged to decriminalise ganja in order to have Jamaica capitalise on a billion-dollar medical ganja industry.

 

In his article, Watson explained that Cannabitriol is a new cannabinoid.

 

"In simple terms, cannabinoids are the typical or characteristic chemicals found in the family of plants called Cannabaceae of which Cannabis is a member or genus," Watson said.

 

"Within this genus there are actually three species of Cannabis, but only two are well-known. The two are Cannabis indica, which is popularly known as hemp, and Cannabis sativa, known locally as ganja, but is also known elsewhere as marihuana or marijuana. The third and much less known species is Cannabis ruderalis, found mainly in central Russia," said Watson, who heads the Scientific Research Council.

 

"Cannabis sativa is the only species cultivated in Jamaica to date and is sometimes called hemp, in error," he said, adding that there are more than 85 known cannabinoids in Cannabis, but these chemicals are also produced naturally in the immune and nervous systems of humans and animals. Watson said that although the structural framework of THC and CBT is different from that of Cannabidiol (CBD), another well-known cannabinoid, a comparison can be made.

 

"The ending 'diol' in CBD indicates the presence of two alcoholic groups. In this case, one group is an alcohol and the other a phenol. CBT, on the other hand, has two alcoholic groups and a phenolic group," the scientist said.

 

"Cannabidiol is credited with curing a number of ailments including seizures, diabetes, cancers of various types, rheumatoid arthritis, inflammation and pain, among others, while having no known adverse side effect.

 

"Very importantly, it has been found to be an antidote to THC, meaning that CBD reduces the psychoactive effect of THC," he said.

 

According to Watson, a recent study has found THC to restrict and suppress the growth of cancer cells in the brain. "This is encouraging news, given that it was previously documented that THC actually kills lung cancer cells," he said.

 

Watson, however, cautioned that these results should not be interpreted to mean advocacy for widespread, uncontrolled or illegal use of the plant and its extracts.

 

"In this regard, it should be noted that tests are normally done with known quantities of pure chemicals under controlled conditions," he said, and reminded that "smoking of whatever substance can be a threat to good health and longevity".

 

Added Watson: "It is yet to be seen if Cannabitriol is psychoactive or has any curative powers. Clinical tests will have to be done; first with mice and then with humans, depending on the results obtained with the mice. This is usually a long and, most times, a very expensive process."

 

He said, too, that a potential difficulty with further work is that while THC and CBD are found in relative abundance in the two well-known species of Cannabis, Cannabitriol has been identified only in very small amounts.

 

"A chemical with some similarities was identified in Japanese ganja, but the scientists did not establish a structure to allow for meaningful comparison," Watson said.

 

[trichcycler]

ooooweeeee, finally our ganja hits the labs for further testing !  we might have only scratched the surface with this seed of reknown ?

[Restorium2]

ooooweeeee, finally our ganja hits the labs for further testing !  we might have only scratched the surface with this seed of reknown ?

Clinical tests will have to be done; first with mice and then with humans,

[trichcycler]

.....my patients have been testing my Golden Back Gorilla Jamaican strain for a couple years with great results. skip the mice, on to the men

Clinical tests will have to be done; first with mice and then with humans,

[Restorium2]

.....my patients have been testing my Golden Back Gorilla Jamaican strain for a couple years with great results. skip the mice, on to the men

And THEN the sample goes to the lab to try and figure out what the PATIENTS told you, so you might learn something to help you repeat good results and stay away from bad results. Of course the lab testing you can afford to get done here in Michigan isn't going to tell you a whole lot.

[trichcycler]

I forego lab testing. For the most part I treat patients with sever pain. It only takes a sample to know if they respond favorably. I would never say "this strain works for this ailment", but maybe " this strain works well for my patient". If I was supplying an alternative healing center I would be using a lab to certify extractions as safe and free of contaminants. Without lab controls in the garden, lab results could vary.

[Restorium2]

I forego lab testing. For the most part I treat patients with sever pain. It only takes a sample to know if they respond favorably. I would never say "this strain works for this ailment", but maybe " this strain works well for my patient". If I was supplying an alternative healing center I would be using a lab to certify extractions as safe and free of contaminants. Without lab controls in the garden, lab results could vary.

If you were the supplier you should already know about contaminants. Someone sneaking something in on you?

[trichcycler]

I do know about contaminants, and that's exactly why mentioned. For instance, in a dirt growing environment you will not be able to detect ever present mold spores in the garden, or on the finished flowers. These are generally not a concern, except to the immune suppressed.  In an organically fertilized garden other contaminations may or may not be a concern, such as ecoli from composted poops or the like, and maybe pest excrement. These contaminants, and their  respective amounts, cannot be detected in the grow room with any amount of accuracy, but a laboratory will detect them, and report accordingly back to the grower. They will be able to inform a grower of exactly the amount of material is in a sample, that is not cannabis.

I see very little pests in my situation, but a gnat is present occasionally. They eat mold, and they poop too. I don't grow in a laboratory setting, nor do I think its necessary, except for the immune suppressed maybe. I have a thousand dollars worth of air scrubbers, and maintain a dry sealed environment. Probably more anal about it than most, and guarantee contaminants are detectable. Could be a spot of dirt, a hair, or maybe a stuck gnat once in awhile. Its a plant, in a dirt garden, cultivated by a farmer. Unfortunately our flowers cant be washed before using, so I pay extra special attention to cleanliness and purity, but my eyes aren't bionic either.

 

Nobody ever gets to see, smell, or touch my garden plants, or finished product except me, and then the designated patient.

If you were the supplier you should already know about contaminants. Someone sneaking something in on you?

[Restorium2]

Filters take out all that stuff. That's why I posted that filter pic for you over in your tools of the trade thread.

[trichcycler]

if you apply water to soil, no filter removes "all that stuff" from your room. I have filters running 24/7, charcoal, hepa, and in a room with no plants, dirt, maybe they would provide an absolute "clean" but not with plants, dirt, water, and fertilizer being used. Mine air is clean, but I'm not fooled.

[Restorium2]

if you apply water to soil, no filter removes "all that stuff" from your room. I have filters running 24/7, charcoal, hepa, and in a room with no plants, dirt, maybe they would provide an absolute "clean" but not with plants, dirt, water, and fertilizer being used. Mine air is clean, but I'm not fooled.

Go back over to your tools thread and refresh your memory about what I'm talking about. Hint; It's not an air filter.

[GregS]

Is a major study by the National Cancer Institute at the National Institutes of health not enough science to permit Obama via Holder to reclassify the drug? The potus just said that he will use all of his presidential privilege to work around Congress. The DEA is an administrative government agency and answers to the President. Lab studies on rodents is old news. The results are remarkable.

 

 

http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page4

 

There are several pages.

 

WE ARE the walking, talking human study subjects, and the results are in as far as I can judge.

Edited February 3, 2014 by GregS

[Restorium2]

 

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Diabetes / Metabolic Disease

 

 

 

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Inflammation

 

 

 

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Gut feelings about the endocannabinoid system.

 

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Link:

 

Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis.

 

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Oncology

 

 

 

Enhancing the activity of cannabidiol and other cannabinoids in vitro through modifications to drug combinations and treatment schedules.

 

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Cannabidiol, a Non-Psychoactive Cannabinoid Compound, Inhibits Proliferation and Invasion in U87-MG and T98G Glioma Cells through a Multitarget Effect.

 

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Cannabinoids: a new hope for breast cancer therapy?

 

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Towards the use of cannabinoids as antitumour agents.

 

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Cannabidiol inhibits angiogenesis by multiple mechanisms.

 

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Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer.

 

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The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK.

 

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Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition.

 

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Cannabinoids as potential new therapy for the treatment of gliomas.

 

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Cannabinoids and gliomas.

 

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Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis.

 

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Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation.

 

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Psychiatric Illness

 

 

 

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Neural mechanisms for the cannabinoid modulation of cognition and affect in man: a critical review of neuroimaging studies.

 

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Cannabidiol and clozapine reverse MK-801-induced deficits in social interaction and hyperactivity in Sprague-Dawley rats.

 

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Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology.

 

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Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug.

 

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Cannabidiol reverses MK-801-induced disruption of prepulse inhibition in mice.

 

Long LE, Malone DT, Taylor DA. Neuropsychopharmacology. 2006 Apr;31(4):795-803.

[trichcycler]

I know the filter you speak of. works great for oil, but dried buds clog it quickly. The contaminations most likely found on flowers in the room. I don't provide oil to anyone anymore, and never did "filter" it with those. Hell, now, I just shake the buds through a micro screen and collect my dusty treasures.

[Restorium2]

I know the filter you speak of. works great for oil, but dried buds clog it quickly. The contaminations most likely found on flowers in the room. I don't provide oil to anyone anymore, and never did "filter" it with those. Hell, now, I just shake the buds through a micro screen and collect my dusty treasures.

We were talking about extracts were we not?

 

grassmatch QUOTE: I would be using a lab to certify extractions as safe and free of contaminants

[trichcycler]

We were talking about extracts were we not?

 

grassmatch QUOTE: I would be using a lab to certify extractions as safe and free of contaminants

nope, buds, gardens. I don't use labs, and would ONLY  use them to find contaminants in an extract intended for use by an immune suppressed patient. Otherwise, we were discussing contaminants in the garden, on the flowers. "For instance, in a dirt growing environment you will not be able to detect ever present mold spores in the garden, or on the finished flowers"

[Restorium2]

I forego lab testing. For the most part I treat patients with sever pain. It only takes a sample to know if they respond favorably. I would never say "this strain works for this ailment", but maybe " this strain works well for my patient". If I was supplying an alternative healing center I would be using a lab to certify extractions as safe and free of contaminants. Without lab controls in the garden, lab results could vary.

You can use a specialized filter to help make sure that your extractions are free from contaminants. Then you wouldn't have to depend on a lab.

[GregS]

Thanks for posting those referenced works Resto. The effin' science is there. Now we need to call Obama out on his remarks. Drugs can be rescheduled through the Justice Department following a thorough review of the science. I cannot imagine them getting anything more authoritative than government funded published research.

Edited February 3, 2014 by GregS

[trichcycler]

true enough,  extractions are halted here for awhile, and I aint no medical lab, so no testing in my future. I don't aspire to be treating the immuno suppressed thankfully. If I did, I suspect an oncologist would want to "purify" a homemade extraction before injecting it into a brain tumor, rather than counting on my new micro screen technique at home. I like being a dirt farmer, more than a lab rat. lol

You can use a specialized filter to help make sure that your extractions are free from contaminants. Then you wouldn't have to depend on a lab.

[Restorium2]

true enough,  extractions are halted here for awhile, and I aint no medical lab, so no testing in my future. I don't aspire to be treating the immuno suppressed thankfully. If I did, I suspect an oncologist would want to "purify" a homemade extraction before injecting it into a brain tumor, rather than counting on my new micro screen technique at home. I like being a dirt farmer, more than a lab rat. lol

The advice was for anyone, especially if you suspect mold in your extract. I learned it from Skunkworks.

[Chauncy Gardner]

Boy. The government is in one huge sh*t pile when it comes to cannabis. Every frickin day there is something new and positive that comes out about cannabis. The positives outweigh the negatives by, what, 1000% now? Yet they still keep their heels dug in, hoping like heck that a new study will come out that proves that cannabis really does make men grow mammary glands.

 

They are screwed. They just don't realize it yet.

[trichcycler]

moldy buds belongs in the compost

suspected moldy extract, in the garbage.

The advice was for anyone, especially if you suspect mold in your extract. I learned it from Skunkworks.