Clinical Endocannabinoid Deficiency

[dpg710]

Not sure if many have heard of this, but it sure does sound like a reason why so many of us find relief through the use of medical cannabis. This article is posted by SensiSeeds, a cannabis seed bank, so keep that in mind while reading. There are plenty of other articles and journals out there on this proposed disorder (I believe GW Pharma was doing some research on it back in 03 or 04) but they all cost money and I am cheap  

 

http://sensiseeds.com/en/blog/what-is-clinical-endocannabinoid-deficiency/

 

I would be interested to hear from others who experience similar symptoms, and what their preferred method of dosage and level of relief from symptoms they get. 

 

For me I have found vaporizing concentrates provides the 2nd best relief, but with the fastest onset. Medicated edibles/capsules/etc provide the most symptom relief, but onset takes a while, and dosage is hard especially with food products. I prefer capsules to food. Smoking is the least effective method for me, and I always feel more "stoned", which I don't enjoy. 

 

 

[AmishRnot4ganja]

Wow. I have often wondered if there is some deficiency that cannabis cures because I feel more"normal" when I have some cannabis in my system. I have also often thought that if I told anyone this that they would think "it's the drug talking". I am now thinking that science may eventually prove what I suspect. I hope that the religious right doesn't outlaw science first though.

[+washtenaut]

Wow. I have often wondered if there is some deficiency that cannabis cures because I feel more"normal" when I have some cannabis in my system. I have also often thought that if I told anyone this that they would think "it's the drug talking". I am now thinking that science may eventually prove what I suspect. I hope that the religious right doesn't outlaw science first though.

 

http://michiganmedicalmarijuana.org/topic/35101-prozac-like-effect-of-cannabis/?hl=imbalance

 

 

The discussion didn't go very far but we started to talk about this one before

[in vivo]

The full article can be downloaded for free here.

 

I recommend all chronic pain patients investigate was in which to increase their levels of endogenous cannabinoids. Dietary linoleic acid raises anandamide and 2-AG, as an example. 

[trichcycler]

conjugated linoleic acid has been all but removed form our diet as a result of the feedlot. The CLA is produced in the fat and muscle of cattle when they are grass fed.

eating from organically fed cow will remedy the issue, and will reduce a waistline. Australia has some comprehensive studies on their beef compared to ours with CLS as their focus.

 

edit;I understand there are only two life forms on the planet with cannabinoid receptors, us and a deep see creature(wtf?)  .

Edited February 25, 2014 by grassmatch

[in vivo]

I think all vertebrates have an ECS.

[trichcycler]

can you verify another animal with cbd receptors in the brain ?  I could be lying, I've seen myself do it..  ; )

 

edit for; you are correct sir.

Edited February 25, 2014 by grassmatch

[trichcycler]

aha, I misspoke. I do see some different cbd receptors, and have more reading to do obviously.

[in vivo]

What's even more fun is when you think you have a handle on a theory, it's debunked, and you get to start over. That's why I now start my searches from 2010 to present. This information is growing at an exponential rate.

[GregS]

can you verify another animal with cbd receptors in the brain ?  I could be lying, I've seen myself do it..  ; )

 

edit for; you are correct sir.

My dog told me he does.

[imiubu]

Ester Fride

 

Cannabinoids and Feeding:
The Role
of the Endogenous Cannabinoid System
as a Trigger for Newborn Suckling
Ester Fride
SUMMARY. Cannabinoids are known to enhance appetite by activating
cannabinoid (CB1) receptors. This phenomenon is exploited to combat
cachexia and loss of appetite in cancer and AIDS patients. The
endocannabinoid 2-arachidonylglycerol (2-AG) is present in milk. Evidence
is presented supporting a critical role for CB1 receptors in survival of
mouse pups. Thus neonates do not gain weight and die within the first week
of life when their receptors are blocked. This is due apparently, to an inability
to ingest maternal milk. This suggests that the endocannabinoid-CB1 receptor
system is unique in its absolute control over the initiation of the
neonatal milk suckling response. It is further proposed that cannabis-based
medicines should be developed to benefit infant failure to thrive. [Article
copies available for a fee from The Haworth Document Delivery Service:
1-800-HAWORTH. E-mail address: <getinfo@haworthpressinc. com> Website:
<http://www.HaworthPress.com> 2002 by The Haworth Press, Inc. All rights reserved.]
Ester Fride, PhD, is Associate Professor, Department of Behavioral Sciences, and
Head, Laboratory of Behavioral Biology, College of Judea and Samaria, Ariel, Israel
44837.
This work was supported in part by a grant from the Danone Research Institute in
Israel.
http://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=4&ved=0CEgQFjAD&url=http%3A%2F%2Fwww.cannabis-med.org%2Fdata%2Fpdf%2F2002-03-04-3.pdf&ei=HTgNU9fHJaWbygGghIGoDA&usg=AFQjCNHI7JAKzm4soUJXrbtRf-f9trxbWA&sig2=aOZHWP7C_ydoGZPpwjvqQw